In general, bison meat can be cooked as you would similar cuts of beef and substituted in beef recipes. The only important consideration is to take its faster cooking rate into account so it doesn’t overcook and dry out. Because bison is much higher in protein and also a little denser in texture, you’re likely to get full with smaller portions.
Bison stew meat makes excellent stews, chilies, and other braised dishes. Season the cubes of bison with salt, pepper, and any other desired spices. Consider making your stews and braises with rich, rustic flavors like chilies, beer, cumin, red wine, rosemary, and sage.
Sear stew meat on all sides in an oiled pan and add to other ingredients to create a stew or braise. Bring the liquid to a simmer, cover, and slow cook in the oven or on the stove top until tender.